An academic article from Clinical Infectious Illnesses states that depression impacts the defense mechanisms by diminishing the varicella zoster virus-cell mediated immunity (VZV-CMI) reaction to a zoster vaccine. This could result in a greater risk and harshness of herpes zoster (HZ). Management of depression through mao inhibitors can normalize the reactions. Therefore without treatment depression boosts the severity and chance of HZ and reduces zoster vaccine effectiveness.
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