A Treatment Of Systemic Herpes
Article by Tutu
Acycloguanosine is an anti-herpes drug that is frequently prescribed to combat various strains of the herpes virus, most notably herpes simplex virus type 1. Since the raw crystalline powder has the lengthy chemical name of 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one, it is most commonly referred to in clinical settings as acycloguanosine. However, it is marketed as a pharmaceutical under the trade names Cyclovir,Acyclovir, Acivir, Zovirax, and Herpex, with the medication being recognized as the standard International Non-proprietary Name for this drug.
Forms and DosageThe drug comes in tablet, capsule, or liquid form, which may contain 200, 400, or 800mg of active ingredient. It is formulated into topical creams for the treatment of herpes simplex outbreaks affecting the mouth or genitals. In addition, the drug is available as an ophthalmic ointment or drops on a three percent concentration to treat keratitis of the cornea. It may also be given by injection in 25mg/mL concentration to immunosupressed patients that are infected with varicella-zoster, the virus that causes chicken pox in children and shingles in adults.
FunctionAs being highly selective toward thymidine kinase, an enzyme “programmed” by herpes simplex and varicella-zoster, this drug has the ability to inhibit viral replication. This promotes a chain of enzymatic reactions and phosphorylation to bring about the conversion of Acyclovir to acyclovir monophosphate and ultimately to acyclovir triphosphate. The antiviral actvity triggered by these events can be observed both in vitro and in vivo, which means outside as well as inside the body, respectively. In addition, acycloguanosine is a prodrug, meaning that it becomes active when introduced into the body in an inactive form and subsequently metabolized. This is fortunate since the drug is otherwise poorly absorbed.
For HerpesHerpes is a very common viral infection, and a majority of humans in most populations will have been exposed to at least one strain of this virus by the time they reach late middle-age. A herpes infection typically produces painful lesions that ooze for a short period and then scab over and begin to heal. The infection remains dormant in the body after this and may break out to produce lesions again at a later date.
No drug can cure herpes, or any other viral infection, but antiviral medications such as acycloguanosine(CAS No. 59277-89-3) can help the body to gain the upper hand in the struggle against a viral infection. The use of acyclovir for herpes treatment is part of standard medical practice in most regions because this drug is typically highly effective. This drug is most effective when administered intravenously but is still generally potent when given orally. Almost all strains of the herpes simplex virus respond well to treatment with this medicine, although limited resistance does occasionally emerge.
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Tutu, 24 years old,male, from hangzhou.
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